ESGE Research
The ESGE Research Committee aims to establish, discuss and promote clinical research studies in digestive endoscopy on a broad European level. For this purpose two modules fulfilling differing criteria, Study Types I and II, have been set up for research projects.
Criteria for Study Type I
- easy to perform
- open to a large number of centres throughout Europe
- with a simple and clearly defined objective
- adhering to common guidelines
- requiring no ethical committee approval in a large majority of countries
Criteria for Study Type II
- evaluating a new approach or new material
- classified phase II or randomized phase III
- open to a limited number of centres
- requiring ethical committee approval
Below are introductions to the existing protocols. Should you wish to partake in these studies please complete the corresponding electronic application form which can be accessed below.
To participate:
- Read the protocols and the CRF.
- If you are interested in adding patients to a protocol, please complete the application form corresponding to the protocol in question.
- After approval of your application you will receive a log-in as participating centre and further instructions for entering your first case.
ESGE Study Type I - Eurosquam
Lugol staining is a highly accurate method of diagnosing superficial esophageal squamous-cell carcinoma (ESCC). However, chromoendoscopy in general, including Lugol staining, is not a popular technique in Europe and is considered to be both time and money consuming. On the other hand, despite the widespread use of upper gastrointestinal endoscopy and advances in mucosal resection, the numbers of cases of superficial ESCC detected in Western countries are low in comparison with Japan.
Screening in Europe should be targeted at the main group of high-risk patients – those with a history of ear, nose, and throat (ENT) carcinoma. In this group, the incidence of associated ESCC is in the range of 2–13%. The purpose of the ESGE's Eurosquam study is to provide a large-scale assessment of the European incidence of ESSC in patients with a history of ENT carcinoma, in order to provide data for a debate regarding organized screening. An indirect aim of the study is to promote the more widespread use of Lugol staining.
The Eurosquam study is designed for publication in a very short case report form (two pages).
The ESGE Study Eurosquam Protocol ( PDF file, 16kB 
)
The ESGE Study Eurosquam CRF ( PDF file, 64kB )
ESGE Study Type I - Euroba
There have been few studies on the carcinoma risk in short-segment Barrett's esophagus (BE), and published reports include only small numbers of patients. In particular, the risk associated with tongues of BE has not yet been specifically studied in a large multicenter cohort study. Several guidelines published by various national societies recommend close follow-up for patients with short-segment Barrett's, including tongues, particularly as the incidence of adenocarcinoma in the cardia is increasing in Western countries. The purpose of this study is to determine, in an easily conducted study in a large series, the incidence of high-grade dysplasia and carcinoma that is observed when the usual guidelines for follow-up are applied - what is the real risk? Follow the guidelines, fill in the electronic case report form, and we will have the answer.
The ESGE Study Euroba Protocol ( PDF file, 32kB )
The ESGE Study Euroba CRF ( PDF file, 162kB )
ESGE Study Type II - Eurobil 1
Acute biliary pancreatitis is a severe disease with 40% morbidity and 10% mortality. Severe pancreatitis with cholangitis clearly benefits from early endoscopic biliary sphincterotomy (EBS) in terms of morbidity and mortality. In other cases, the relevance of early EBS is not established. Since stone migration might lead to oedematous obstruction of the pancreatic duct and that the duration of obstruction seems to be associated with severity, the following trial was designed.
Randomized multicenter study comparing EBS within 48 hours of symptom onset versus standard treatment: EBS only if stones are present during delayed endoscopic cholangiography.
The ESGE Study Eurobil 1 Protocol ( PDF file, 105kB )
The ESGE Study Eurobil 1 CRF ( PDF file, 102kB )
Applications for a new protocol can be submitted to the ESGE Research Committee via the ESGE Technical Secretariat at the following email address: secretariat@esge.com.
